Perspective: Vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: implications for COVID-19

Vitamin D and Coronavirus Disease (COVID-19); Is Deficiency and Maintenance Supplementation Therapy Necessary?

Vitamin D is a fat soluble vitamin with a well-known general metabolism and actions in bone structure and immune system regulation. Vitamin D exhibits direct antimicrobial activities against a spectrum of microbes, including Gram-positive and Gram-negative bacteria, enveloped and non-enveloped viruses, as well as fungi. An observational study showed that concentrations of 38 ng/ml or more were ...

Vitamin D-deficiency rickets in two breast-fed infants who were not receiving vitamin D supplementation.

Letter: Covid-19, and vitamin D

Vitamin D is an immune modulator hormone with an anti-inflammatory effect. In this study the potential association between vitamin D and risk of Covid-19 disease were examined. Data of worldwide mortality rate of Covid-19 pandemic according to geographical distribution in 108 countries were analyzed. The results shows Covid-19 outbreaks and particularly mortality exhibit a decreasing North-Sout...

Review: vitamin D plus calcium, but not vitamin D alone, prevents osteoporotic fractures in older persons.

M e t h o d s Data sources: 10 databases, lists of conference abstracts, bibliographies of relevant studies, and contact with researchers in the field. Study selection and assessment: Randomized and quasi-randomized controlled trials (RCTs) that compared vitamin D or a vitamin D analogue (alone or in combination with calcium) with placebo, no intervention, or calcium alone in postmenopausal wom...

Review Vitamin D and respiratory infections

Vitamin D or 1,25-hydroxyvitamin D (1,25(OH)2 D) has a well-established role in calcium homeostasis. In recent years, the discovery of vitamin D-metabolizing enzymes and vitamin D receptor (VDR) in the lungs and various cells of the immune system has led to numerous studies conducted to evaluate its role in respiratory functions and, in particular, upper respiratory tract infections (URTIs). A ...